Skip to main content
  • Home
  • Articles
    • Archive from 2022 July
    • Archive 1960 to 2022 June
    • Accepted Articles
    • Published Ahead-of-Print
    • Supplement
  • About
  • For Authors
  • Podcasts

A case of systemic nocardiosis in systemic vasculitis and a review of the literature

< Back to Listing

Share this Article

Singapore Med J 2013; 54(6): e127-e130; http://dx.doi.org/10.11622/smedj.2013098
A case of systemic nocardiosis in systemic vasculitis and a review of the literature

  • Abstract
  • PDF
  • References

Sirisena D, Al Swedan L, Jayne D, Chakravarty K
Correspondence: Dr Dinesh Sirisena, dineshsirisena@doctors.org.uk

ABSTRACT
Systemic nocardiosis is rarely reported in patients with systemic vasculitis, and is mostly described in patients experiencing long-term immunosuppression following organ transplantation. In this report, we describe a 71-year-old man who developed disseminated Nocardia infection during treatment of his underlying microscopic polyangiitis. He had no other associated risk factors. This case highlights the importance of considering rare pathogens in immunosuppressed patients who present with nonspecific symptoms, as well as the impact of such pathogens on clinical management.

Keywords: immunosuppression, microscopic polyangiitis, nocardiosis nova, systemic nocardiosis, systemic vasculitis
Singapore Med J 2013; 54(6): e127–e130; http://dx.doi.org/10.11622/smedj.2013098

http://smj.org.sg/sites/default/files/5406/5406cr4.pdf

REFERENCES

1. Sullivan DC, Chapman SW. Bacteria that masquerade as fungi: actinomycosis/nocardia. Proc Am Thorac Soc 2010; 7:216-21.
http://dx.doi.org/10.1513/pats.200907-077AL
 
2. Peleg AY, Husain S, Qureshi ZA, et al. Risk factors, clinical characteristics, and outcome of Nocardia infection in organ transplant recipients: a matched case-control study. Clin Infect Dis 2007; 44:1307-14.
http://dx.doi.org/10.1086/514340
 
3. Provost F, Laurent F, Blanc MV, Boiron P. Transmission of nocardiosis and molecular typing of Nocardia species: a short review. Eur J Epidemiol 1997; 13:235-8.
http://dx.doi.org/10.1023/A:1007324214800
 
4. Kanne JP, Yandow DR, Mohammed TL, Meyer CA. CT findings of pulmonary nocardiosis. AJR Am J Roentgenol 2011; 197:W266-72.
http://dx.doi.org/10.2214/AJR.10.6208
 
5. Dodiuk-Gad R, Cohen E, Ziv M, et al. Cutaneous nocardiosis: report of two cases and review of the literature. Int J Derm 2010; 49:1380-5.
http://dx.doi.org/10.1111/j.1365-4632.2010.04554.x
 
6. Kilincer C, Hamamcioglu MK, Simsek O, et al. Nocardial brain abscess: review of clinical management. J Clin Neurosci 2006; 13:481-5.
http://dx.doi.org/10.1016/j.jocn.2005.04.031
 
7. Tabrizi SJ. Nocardia pericarditis. BMJ 1994; 309:1495-7.
http://dx.doi.org/10.1136/bmj.309.6967.1495
 
8. Lapraik C, Watts R, Bacon P, et al. BSR and BHPR guidelines for the management of adults with ANCA associated vasculitis. Rheumatology (Oxford) 2007; 46:1615-6.
http://dx.doi.org/10.1093/rheumatology/kem146a
 
9. Yew S, Jayne D, Hoglund P, et al. The disease characteristics of ANCA associated vasculitis: 735 patients recruited at diagnosis to six European vasculitis study group trials (abstract). Nephrology 2012; 17(2 suppl): 45.
 
10.Flohr TR, Sifri CD, Brayman KL, et al. Nocardiosis in a renal transplant recipient following Rituximab preconditioning. Ups J Med Sci 2009; 114:62-4.
http://dx.doi.org/10.1080/03009730802604931
 
11. Kundranda MN, Spiro TP, Muslimani A, et al. Cerebral nocardiosis in a patient with NHL treated with rituximab. Am J Hematol 2007; 82:1033-4.
http://dx.doi.org/10.1002/ajh.20921
 
12.Brown-Elliott BA, Brown JM, Conville PS, Wallace RJ Jr. Clinical and laboratory features of Nocardia spp. based on current molecular taxonomy. Clin Microbiol Rev 2006; 19:259-82.
http://dx.doi.org/10.1128/CMR.19.2.259-282.2006
 
13. Saubolle MA, Sussland D. Nocardiosis: review of clinical and laboratory experience. J Clin Microbiol 2003; 41:4497-501.
http://dx.doi.org/10.1128/JCM.41.10.4497-4501.2003
 
14. Lerner PI. Nocardiosis. Clin Infect Dis 1996; 22:891-903.
http://dx.doi.org/10.1093/clinids/22.6.891
 
15. Simpson GL, Stinson EB, Egger MJ, Remington JS. Nocardial infections in the immunocompromised host: A detailed study in a defined population. Rev Infect Dis 1981; 3:492-507.
http://dx.doi.org/10.1093/clinids/3.3.492
 
16.Clinicopathologic conference. Headache, mental status changes and death in a 36-year-old woman with lupus. Am J Med 1989; 86:94-102.
http://dx.doi.org/10.1016/0002-9343(89)90237-4
 
17. Cianfoni A, Calandrelli R, De Bonis P, et al. Nocardia brain abscess mimicking high-grade necrotic tumor on perfusion MRI. J Clin Neurosci 2010; 17:1080-2.
http://dx.doi.org/10.1016/j.jocn.2009.10.039
 
18.Malincarne L, Marroni M, Farina C, et al. Primary brain abscess with Nocardia farcinica in an immunocompetent patient. Clin Neurol Neurosurg 2002; 104:132-5.
http://dx.doi.org/10.1016/S0303-8467(01)00201-3
×

Around the Site

Home

About SMJ

For Reviewers

Sign Up for Alerts

Issues

Current Issue

All Issues

Online First

Supplement

CME

For Authors

Instructions for Authors

Submit Manuscript


Follow us on:
        

More Links

Contact Us

Copyright

Advertise

SMJ Forms

Privacy Policy

SMA Home

Copyright 2021. Singapore Medical Association. All Rights Reserved.