Chronic neutrophilic leukaemia

Gan GG, Pasagna JJF, Eow GI, Nadarajan VS
Correspondence: Dr Gan Gin Gin, gingingan@yahoo.com

ABSTRACT
Chronic neutrophilic leukaemia is a rare myeloproliferative disease characterised by splenomegaly, sustained neutrophilia, raised vitamin B12 level and absence of the Philadelphia chromosome. We report a 74-year-old man who presented first with Sweet's syndrome and subsequently leukocytosis. He had splenomegaly, a raised vitamin B12 level, serum uric acid and neutrophil alkaline phosphatase score. Cytogenetic study of the marrow was normal and peripheral blood for BCR-ABL gene transcript was not detectable. He subsequently passed away with bronchopneumonia.

Keywords: chronic neutrophilic leukaemia, leukaemia, neutrophilia, Sweet’s syndrome
Singapore Med J 2007; 48(3): e74–e76