Singapore Med J 2014; 55(4): e52-e53; http://dx.doi.org/10.11622/smedj.2014059
From divination to madness: features of acute intoxication with Salvia use
Winslow MR, Mahendran R
Correspondence: Dr R Mahendran, medrm@nus.edu.sg
ABSTRACT
Salvia divinorumis a psychoactive botanical plant that is increasingly used for the ‘legal’ highs that it can produce. It is readily available for purchase on the Internet, and most abusers are unaware of the toxicity and abuse potential associated with its use. As the use of novel compounds among abusers is not uncommon, physicians need to increase their awareness and recognition of these new substances. Herein, we report a case of an acute presentation of Salvia intoxication.
Keywords: psychiatric symptoms, Salvia divinorum
Singapore Med J 2014; 55(4): e52–e53; http://dx.doi.org/10.11622/smedj.2014059
REFERENCES
1. Valdés LJ 3rd, Díaz JL, Paul AG. Ethnopharmacology of the ska Maria Pastora (Salvia divinorum, Epling and Játiva-M.). J Ethnopharmacol 1983; 7:287-312.
http://dx.doi.org/10.1016/0378-8741(83)90004-1 |
| |
| 2. Lim M, Tan YY, Lee TK. Unusual Seizures in Singapore. Abstract. Available at: www.hsa.gov.sg. Accessed February 28, 2013. |
| |
3. Przekop P, Lee T. Persistent psychosis associated with Salvia divinorum use. Am J Psychiatry 2009; 166:832.
http://dx.doi.org/10.1176/appi.ajp.2009.08121759 |
| |
4. Singh S. Adolescent salvia substance abuse. Addiction 2007; 102:823-4.
http://dx.doi.org/10.1111/j.1360-0443.2007.01810.x |
| |
5. Bucheler R, Glerter CH, Schwoeter P, Gaertner I. Use of non-prohibited hallucinogenic plants: increasing relevance for public health? Phramacopsychiatry 2005; 38:1-5.
http://dx.doi.org/10.1055/s-2005-837763 |
| |
6. Hanes KR. Antidepressant effects of the herb Salvia divinorum: a case report. J Clin Psychopharm 2001; 21:634-5.
http://dx.doi.org/10.1097/00004714-200112000-00025 |
| |
7. Prisinzano TE. Psychopharmacology of the hallucinogenic sage Salvia. Life Sci 2005; 78:527-31.
http://dx.doi.org/10.1016/j.lfs.2005.09.008 |
| |
8. Albertson DN, Grubbs LE. Subjective effects of Salvia divinorum: LSD- or marijuana-like? J Psychoactive Drugs 2009; 41:213-7.
http://dx.doi.org/10.1080/02791072.2009.10400531 |
| |
9. Carlezon WA Jr, Béguin C, DiNieri JA, et al. Depressive-like effects of the kappa-opiod receptor agonist salvinorin A on behavior and neurochemistry in rats. J Pharmacol Exp Ther 2006; 316:440-7.
http://dx.doi.org/10.1124/jpet.105.092304 |
| |
10. Grundmann O, Phipps SM, Zadezensky I, Butterweck V. Salvia divinorum and salvinorin A: an update on pharmacology and analytical methodology. Planta Med 2007; 73:1033-46.
http://dx.doi.org/10.1055/s-2007-981566 |
| |
11. Hooker JM, Xu Y, Schiffer W, et al. Phatmacokinetics of the potent hallucinogen salvinorum A in primates parallels the rapid onset and short duration of effects in humans. NeuroImage 2008: 41;1044-50.
http://dx.doi.org/10.1016/j.neuroimage.2008.03.003 |
