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Tennakoon J, Kandasamy Y, Alcock G, Koh THHG
Correspondence: Dr Yoga Kandasamy, email@example.com
Double trisomy is rare and the only case reported in the literature died soon after birth. We present another case of double trisomy (48XYY, +18) in a male neonate, who was born to a 28-year-old gravida three parity one mother at 35 weeks of gestation. The baby had features of trisomy 18. Karyotype of the patient showed 48, XYY, +18, Ish (DYZ3*2), (D18Z1*3), nuc ish (DYZ3*2), (D18Z1*3) . The patient had clinical features of trisomy 18. There was no family history of diabetes mellitus and no exposure to chemicals. It has been suggested that the rarity of Y-chromosome involvement in trisomy 18 may be due to discrepancy between the sexes.
Keywords: double trisomy, Edwards syndrome, gonosomal trisomy, karyotype, trisomy 18
Singapore Med J 2008; 49(7): e190-e191