Factor XIII deficiency: a rare cause of repeated abortions

LD Padmanabhan, R Mhaskar, A Mhaskar, CR Ross
Correspondence: Dr Laxmi Devi Padmanabhan, latoshmi@yahoo.co.in

ABSTRACT
Factor XIII deficiency is a rare cause of early abortion. The obstetrical outcome of four pregnancies in two women with factor XIII deficiency is reported. Both women were treated with substitution therapy using locally-prepared cryoprecipitate. The outcome in these two women demonstrated the need for substitution therapy in early pregnancy leading to an increased chance of obstetrical success.

Keywords: bleeding disorders, factor XIII deficiency, pregnancy, repeated abortions
Singapore Med J 2004; 45(4): 186-187