Singapore Med J 2014; 55(1): e17-e19; http://dx.doi.org/10.11622/smedj.2013188
Isoniazid-induced cerebellitis: a disguised presentation
Peter P, John M
Correspondence: Dr Prasant Peter, prasant.peter@rediffmail.com
ABSTRACT
Cerebellitis is a rarely encountered complication of isoniazid therapy. Its occurrence is usually associated with concomitant renal disease and haemodialysis. Herein, we report the case of a patient with this complication who presented with isolated bilateral symmetrical dentate nucleus T2 hyperintensities on magnetic resonance imaging. Isoniazid neurotoxicity has never been reported to cause bilateral dentate hyperintensities, for which the differentials are few and include metronidazole toxicity.
Keywords: bilateral dentate nuclei, cerebellitis, chronic kidney disease, isoniazid
Singapore Med J 2014; 55(1): e17-e19; http://dx.doi.org/10.11622/smedj.2013188
REFERENCES
| 1. Tan M, Alkan O, Karaca S, Karakurum Goksel B, Demiroglu YZ. Cerebellitis due to Antituberculosis Therapy in a Patient with Chronic Renal Failure. F?rat T?p Dergisi 2009; 14:290-2. |
| |
| 2. Blumberg EA, Gil RA. Cerebellar syndrome caused by isoniazid. DICP 1990; 24:829-31. |
| |
| 3. Lewin PK, McGreal D. Isoniazid toxicity with cerebellar ataxia in a child. CMAJ 1993; 148:49-50. |
| |
4. Siskind MS, Thienemann D, Kirlin L. Isoniazid-induced neurotoxicity in chronic dialysis patients: report of three cases and a review of literature. Nephron 1993; 64:303-6.
http://dx.doi.org/10.1159/000187331 |
| |
5. De Bruecker Y, Claus F, Demaerel P, et al. MRI findings in acute cerebellitis. Eur Radiol 2004; 14:1478-83.
http://dx.doi.org/10.1007/s00330-004-2247-y |
| |
6. Kim E, Na DG, Kim EY, et al. MR imaging of metronidazole-induced encephalopathy: lesion distribution and diffusion-weighted imaging findings. AJNR Am J Neuroradiol 2007; 28:1652-8.
http://dx.doi.org/10.3174/ajnr.A0655 |
| |
7. Kalia V, Vibhuti, Saggar K. Case report: MRI of the brain in metronidazole toxicity. Indian J Radiol Imaging 2010; 20:195-7.
http://dx.doi.org/10.4103/0971-3026.69355 |
| |
8. Kang SY, Kang JH, Choi JC, Choi G. Wernicke's encephalopathy: unusual manifestation on MRI. J Neurol 2005; 252:1550-2
http://dx.doi.org/10.1007/s00415-005-0886-9 |
