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Ong CWM, Chua LS, Ng A, Low SY
Correspondence: Dr Catherine WM Ong, firstname.lastname@example.org
Langerhans cell histiocytosis (LCH) is a rare disease characterised by monoclonal proliferation and infiltration of organs by large mononuclear cells. Organs commonly involved include the lungs and pituitary gland. However, the disease association with hypogonadotrophic hypogonadism has not been reported in the literature, to our knowledge. We report a 26-year-old Chinese man with LCH, recurrent pneumothoraces, diabetes insipidus and hypogonadotrophic hypogonadism. The clinical features and management of the disease are reviewed.
Keywords: diabetes insipidus, hypogonadotrophic hypogonadism, interstitial lung disease, Langerhans cell histiocytosis
Singapore Med J 2009; 50(5): e185-e188