Two cases of self-limiting nephropathies secondary to dengue haemorrhagic fever

Vasanwala FF, Puvanendran R, Ng JM, Suhail SM
Correspondence: Dr Farhad Fakhrudin Vasanwala, farhad.fakhrudin.vasanwala@singhealth.com.sg

ABSTRACT
We report two cases of dengue haemorrhagic fever which developed self-limiting gross nephrotic-range proteinuria. One patient was a 32-year-old Bangladeshi and the other a 42-year-old Chinese national. Both patients did not have manifestations of renal damage, such as increase in serum creatinine, haematuria or urinary casts. Gross nephrotic-range proteinuria, which was self-limiting due to dengue haemorrhagic fever, has not been previously reported in Singapore. We postulate that this nephrotic-range proteinuria is a manifestation of increased glomerular leakage of protein, due to glomerulonephritis associated with dengue haemorrhagic fever.

Keywords: dengue haemorrhagic fever, immune complexes, nephrotic-range proteinuria, plasma leakage, self-limiting glomerulonephritis
Singapore Med J 2009; 50(7): e253-e255