Skip to main content
  • Home
  • Articles
    • Archive from 2022 July
    • Archive 1960 to 2022 June
    • Accepted Articles
    • Published Ahead-of-Print
    • Supplement
  • About
  • For Authors
  • Podcasts

Unusual presentation of adult xanthogranuloma

< Back to Listing

Share this Article

Singapore Med J 2014; 55(2): e25-e27; http://dx.doi.org/10.11622/smedj.2013207
Unusual presentation of adult xanthogranuloma

  • Abstract
  • PDF
  • References

Tan LX, Aw CW
Correspondence: Dr Tan Lixian Chris, chris_lixian_tan@nuhs.edu.sg

ABSTRACT
Xanthogranulomas are the most common form of non-Langerhans cell histiocytosis. Both adult and childhood forms have been described. Adult cutaneous forms can present as solitary or multiple yellowish, orangered or tan-hued papules. Herein, we present the case of a 28-year-old Chinese man with a skin-coloured nodule on his left nasal ala that persisted for several months. While initial impression was that of a fibrous papule of the nose, the results of an excision biopsy showed histological features corresponding to xanthogranuloma. This case demonstrates the condition’s myriad of dermatological presentations, and adds to the differential diagnoses of a cutaneous lesion found in the head and neck region.

Keywords: adult, adult orbital xanthogranulomatous disease, late onset, xanthogranuloma
Singapore Med J 2014; 55(2): e25-e27; http://dx.doi.org/10.11622/smedj.2013207

http://smj.org.sg/sites/default/files/5502/5502cr3.pdf

REFERENCES

1. Rodriguez J, Ackerman AB. Xanthogranuloma in adults. Arch Dermatol 1976; 112:43- 4.
http://dx.doi.org/10.1001/archderm.1976.01630250015004
 
2. Nayak S, Acharjya B, Devi B, Patra MK. Multiple xanthogranulomas in an adult. Indian J Dermatol Venereol Leprol 2008; 74:67-8.
http://dx.doi.org/10.4103/0378-6323.38419
 
3. Kolde G, Bonsmann G. Generalised lichenoid juvenile xanthogranuloma. Br J Dermatol 1992; 126:66-70.
http://dx.doi.org/10.1111/j.1365-2133.1992.tb08406.x
 
4. Vasconcelos FO, Oliveira LA, Naves MD, Castro WH, Gomez RS. Juvenile xanthogranuloma: case report with immunohistochemical identification of early and late cytomegalovirus antigens. J Oral Sci 2001; 43:21-5.
http://dx.doi.org/10.2334/josnusd.43.21
 
5. Fishman SJ, Brodie S, Popkin G. Juvenile xanthogranuloma. Cutis 1973; 11:499-501.
 
6. Gartmann H, Tritsch H. [Nevoxanthoendothelioma with small and large nodules. Report on 13 cases]. Arch Klin Exp Dermatol Syphilol 1963; 215:409-27. German.
http://dx.doi.org/10.1007/BF00476700
 
7. Lin SJ, Chiu HC. Adult multiple xanthogranulomas with spontaneous resolution. Acta Derm Venereol 2003; 83:157-8.
http://dx.doi.org/10.1080/00015550310007643
 
8. Webster SB, Reister HC, Harman LE Jr. Juvenile xanthogranuloma with extracutaneous lesions. A case report and review of the literature. Arch Dermatol 1966; 93:71-6.
http://dx.doi.org/10.1001/archderm.1966.01600190077017
 
9. Hwang SH, Son EJ, Oh KK, et al. Bilateral xanthogranuloma of the breast: radiologic findings and pathologic correlation. J Ultrasound Med 2007; 26 :535 - 7.
 
10. Parmley VC, George DP, Fannin LA. Juvenile xanthogranuloma of the iris in an adult. Arch Ophthalmol 1998; 116:377-9.
http://dx.doi.org/10.1001/archopht.116.3.377
 
11. Miranda P, Lobato RD, Ricoy JR, Lagares A, Ramos A. Xanthogranuloma of the choroid plexus of the third ventricle: case report and literature review. Neurocirugia (Astur) 2005; 16:518-22.
http://dx.doi.org/10.4321/S1130-14732005000600006
 
12. Sarthou-Bruere S, Milpied-Homsi B, Mahe B, Cassagnau E, Stalder JF. [Eruptive xanthogranulomatosis in a trisomy 21 patient with acute lymphoblastic leukemia]. Ann Dermatol Vénéréol 2000; 127:80-2. French.
 
13. Guo J, Wang J. Adult orbital xanthogranulomatous disease: review of the literature. Arch Pathol Lab Med 2009; 133:1994-7.
 
14. Von Sperling ML, Høimyr H. [Adult onset xanthogranuloma in a 73-year-old woman]. Ugeskr Laeger 2011; 173:1366-7. Danish.
 
15. Janssen D, Harms D. Juvenile xanthogranuloma in childhood and adolescence: a clinicopathologic study of 129 patients from the kiel pediatric tumor registry. Am J Surg Pathol 2005; 29:21-8.
http://dx.doi.org/10.1097/01.pas.0000147395.01229.06
 
16. Sonda T, Hashimoto H, Enjoji M. Juvenile xanthogranuloma. Clinicopathologic analysis and immunohistochemical study of 57 patients. Cancer 1985; 56:2280-6.
http://dx.doi.org/10.1002/1097-0142(19851101)56:9<2280::AID-CNCR2820560923>3.0.CO;2-L
 
17. MacLeod PM. Juvenile xanthogranuloma of the iris managed with superficial radiotherapy. Clin Radiol 1986; 37:295-6.
http://dx.doi.org/10.1016/S0009-9260(86)80355-5
 
18. Klemke CD, Held B, Dippel E, Goerdt S. [Multiple juvenile xanthogranulomas successfully treated with CO2 laser]. J Dtsch Dermatol Ges 2007; 5:30-3. German.
http://dx.doi.org/10.1111/j.1610-0387.2007.06154.x
 
19. Dion LD, Blalock JE, Gifford GE. Retinoic acid and the restoration of anchorage dependent growth to transformed mammalian cells. Exp Cell Res 1978; 117:15-22.
http://dx.doi.org/10.1016/0014-4827(78)90422-6
 
20. Achar A, Naskar B, Mondal PC, Pal M. Multiple generalized xanthogranuloma in adult: case report and treatment. Indian J Dermatol 2011; 56:197-9.
http://dx.doi.org/10.4103/0019-5154.80416
×

Around the Site

Home

About SMJ

For Reviewers

Sign Up for Alerts

Issues

Current Issue

All Issues

Online First

Supplement

CME

For Authors

Instructions for Authors

Submit Manuscript


Follow us on:
        

More Links

Contact Us

Copyright

Advertise

SMJ Forms

Privacy Policy

SMA Home

Copyright 2021. Singapore Medical Association. All Rights Reserved.